Fabrication of monodisperse droplets and microcapsules using microfluidic chips: a review of methodologies and applications

Journal article


Su, W, Han, B, Yeboah, S., Du, D and Wang, L (2023). Fabrication of monodisperse droplets and microcapsules using microfluidic chips: a review of methodologies and applications. Reviews in Chemical Engineering. https://doi.org/10.1515/revce-2022-0060
AuthorsSu, W, Han, B, Yeboah, S., Du, D and Wang, L
Abstract

Microfluidics has been applied in the preparation of monodisperse droplets and microcapsules due to its high encapsulation efficiency, its ability to create uniform particle sizes, and its capacity to control core-shell ratio and structure. To bring to the fore methodologies for the fabrication and application of monodisperse microcapsules using microfluidics, we present a review of the design, structure, materials, and surface modification techniques of various microfluidic chips. The review also covers fabrication methods, operating parameters and regulation methods of single and multiple monodisperse emulsion droplets fabricated from various microfluidic devices. Our findings show that particle size of monodisperse droplets depend mainly on microchannel characteristic size and flow rate, with particle size increasing with larger microchannel but decreasing with higher continuous phase flow rate. We additionally reviewed and compared various fabrication methods for monodisperse microcapsules, such as interfacial polymerization, free-radical polymerization, ionic cross-linking, and solvent evaporation. We further reviewed and examined the application of monodisperse microcapsules in biology applications, food engineering, composite materials development and pharmaceutical industry. We found that high-throughput microfluidics for scale-up monodisperse microcapsule preparation towards uniform degradation and targeted release properties of monodisperse microcapsules would be key innovative direction for future applications.

KeywordsMicrofluidics; Monodisperse droplets; Monodisperse microcapsule; Microencapsulation.
Year2023
JournalReviews in Chemical Engineering
PublisherDe Gruyter
ISSN2191-0235
Digital Object Identifier (DOI)https://doi.org/10.1515/revce-2022-0060
Web address (URL)https://doi.org/10.1515/revce-2022-0060
Publication dates
Online19 May 2023
Publication process dates
Deposited26 May 2023
Accepted26 Mar 2023
Accepted author manuscript
License
File Access Level
Open
Permalink -

https://openresearch.lsbu.ac.uk/item/9411q

Download files


Accepted author manuscript
20230222 Manuscript-R1.docx
License: CC BY 4.0
File access level: Open

  • 59
    total views
  • 8
    total downloads
  • 3
    views this month
  • 3
    downloads this month

Export as

Related outputs

The Impact of Postures and Moving Directions in Fire Evacuation in a Low-Visibility Environment
Yan, J., He, G., Basiri, A., Hancock, C. and Yeboah, S. (2024). The Impact of Postures and Moving Directions in Fire Evacuation in a Low-Visibility Environment. Sensors. 24 (5), p. 1378. https://doi.org/10.3390/s24051378
Investigation of the thermal management potential of phase change material for lithium-ion battery
Wang, H., Guo, Y., Ren, Y., Yeboah, S., Wang, J., Long, F., Zhang, Z. and Jiang, R. (2023). Investigation of the thermal management potential of phase change material for lithium-ion battery. Applied Thermal Engineering. https://doi.org/10.1016/j.applthermaleng.2023.121590
Ecological and Carbon Footprints of Cities
Lina A. Khaddour, Siegfried K. Yeboah, Jacob K. Dodoo and Dr Siegfried Yeboah (2023). Ecological and Carbon Footprints of Cities. in: Earth Systems and Environmental Sciences
Numerical data on fire in the cavity of naturally ventilated double skin façade with Venetian blinds
Huang, Y., Yeboah, S. and Shao, J. (2022). Numerical data on fire in the cavity of naturally ventilated double skin façade with Venetian blinds. Data in Brief. 46, p. 108859. https://doi.org/10.1016/j.dib.2022.108859
Multiple-criteria optimization of residential buildings envelope toward nZEBs: simplified approach for Damascus post-war
Khaddour, L. A. and Yeboah, S. K. (2022). Multiple-criteria optimization of residential buildings envelope toward nZEBs: simplified approach for Damascus post-war. The 3rd International Conference on Energy and Sustainable Futures (ICESF) . Coventry University, UK 07 - 08 Sep 2022 https://doi.org/10.1007/978-3-031-30960-1_21
Numerical investigation of fire in the cavity of naturally ventilated double skin façade with venetian blinds
Huang, Y., Yeboah, S. and Shao, J. (2022). Numerical investigation of fire in the cavity of naturally ventilated double skin façade with venetian blinds. Building Services Engineering Research and Technology. https://doi.org/10.1177/01436244221129763
Adsorption Dataset on a Fully Packed Silica Gel Bed and three Z-Annular Flow Silica Gel Packed Beds
Yeboah, S. Adsorption Dataset on a Fully Packed Silica Gel Bed and three Z-Annular Flow Silica Gel Packed Beds. https://doi.org/10.17632/xzss43z4fw.3
Dataset on Helically Coiled Oscillating Heat Pipe (HCOHP)
Yeboah, S. Dataset on Helically Coiled Oscillating Heat Pipe (HCOHP). https://doi.org/10.17632/wnf5jwzp3c.3
Investigation of a Thermoelectric Generator with PCM for Harvesting Solar Energy
Guo, Y., Ren, Y., Yan, Y. and Yeboah, S. (2021). Investigation of a Thermoelectric Generator with PCM for Harvesting Solar Energy. The 8th Asian Symposium on Computational Heat Transfer and Fluid Flow, Qingdao, Sep. 23-26, 2021. Qingdao, P. R. China 23 - 26 Sep 2021 MDPI.
Experimental data on water vapour adsorption on silica gel in fully packed and Z-annulus packed beds
Yeboah, S. K. and Darkwa, Jo. (2021). Experimental data on water vapour adsorption on silica gel in fully packed and Z-annulus packed beds. Data in Brief. 34 (106736). https://doi.org/10.1016/j.dib.2021.106736
Simulation Study on the Spreading of Fire-Induced Smoke in Natural-Ventilated Double-Skin Facade Buildings
Shao, J., Yeboah, S. K., Zhu, T. and Li, Y. (2020). Simulation Study on the Spreading of Fire-Induced Smoke in Natural-Ventilated Double-Skin Facade Buildings. 11th International Symposium on Heating, Ventilation and Air Conditioning. Harbin, China 12 - 15 Jul 2019 Springer. https://doi.org/10.1007/978-981-13-9528-4_102
Dataset on Helically Coiled Oscillating Heat Pipe (HCOHP)
Yeboah, S. K. and Darkwa, J. (2020). Dataset on Helically Coiled Oscillating Heat Pipe (HCOHP). Mendeley Data. https://doi.org/http://dx.doi.org/10.17632/wnf5jwzp3c.2
Adsorption Dataset on a Fully Packed Silica Gel Bed and three Z-Annular Flow Silica Gel Packed Beds
Yeboah, S. K. and Darkwa, J. (2020). Adsorption Dataset on a Fully Packed Silica Gel Bed and three Z-Annular Flow Silica Gel Packed Beds. Mendeley Data. https://doi.org/10.17632/xzss43z4fw.2
Experimental data on Helically Coiled Oscillating Heat Pipe (HCOHP) design and thermal performance
Yeboah, S. K. and Darkwa, J. (2020). Experimental data on Helically Coiled Oscillating Heat Pipe (HCOHP) design and thermal performance. Data in Brief. 33, p. 106505. https://doi.org/10.1016/j.dib.2020.106505
Experimental investigation into the integration of solid desiccant packed beds with oscillating heat pipes for energy efficient isothermal adsorption processes
Yeboah, S. K. and Darkwa, J. (2020). Experimental investigation into the integration of solid desiccant packed beds with oscillating heat pipes for energy efficient isothermal adsorption processes. Thermal Science and Engineering Progress. 21, p. 100791. https://doi.org/10.1016/j.tsep.2020.100791
Thermal performance of a novel helically coiled oscillating heat pipe (HCOHP) for isothermal adsorption. An experimental study
Yeboah, S. and Darkwa, J. (2018). Thermal performance of a novel helically coiled oscillating heat pipe (HCOHP) for isothermal adsorption. An experimental study. International Journal of Thermal Sciences. 128, pp. 49-58. https://doi.org/10.1016/j.ijthermalsci.2018.02.014
Experimental investigations into the adsorption enhancement in packed beds using Z-Annular flow configuration
Yeboah, S. and Darkwa, J. (2018). Experimental investigations into the adsorption enhancement in packed beds using Z-Annular flow configuration. International Journal of Thermal Sciences . 136, pp. 121-134. https://doi.org/10.1016/j.ijthermalsci.2018.10.027
A critical review of thermal enhancement of packed beds for water vapour adsorption
Yeboah, S. and Darkwa, J. (2016). A critical review of thermal enhancement of packed beds for water vapour adsorption. Renewable and Sustainable Energy Reviews. 58, pp. 1500-1520. https://doi.org/10.1016/j.rser.2015.12.134
Investigations into the thermal performance of a helically coiled closed loop oscillating heat pipe
Yeboah, S. and Darkwa, J. (2016). Investigations into the thermal performance of a helically coiled closed loop oscillating heat pipe. AIAA 2016-4794- AIAA Propulsion and Energy 2016 - 14th International Energy Conversion Engineering Conference. Salt Lake City, UT 25 - 27 Jul 2016 American Institute of Aeronautics and Astronautics (AIAA). https://doi.org/10.2514/6.2016-4794
Numerical investigation of the thermal performance of water based closed loop oscillating heat pipe (CLOHP)
Yeboah, S. and Darkwa, J. (2015). Numerical investigation of the thermal performance of water based closed loop oscillating heat pipe (CLOHP). 14th International Conference on Sustainable Energy Technologies. Nottingham, UK 25 - 27 Aug 2015 University of Nottingham & WSSET.
Thermal Enhancement of Solid Desiccant Packed Bed Dehumidifier Under Forced Convection in Subsonic Flow Regime
Yeboah, S. and Darkwa, J. (2014). Thermal Enhancement of Solid Desiccant Packed Bed Dehumidifier Under Forced Convection in Subsonic Flow Regime. AIAA 2014-3658 -Propulsion Energy Forum - 12th International Energy Conversion Engineering Conference. Cleveland, OH 28 - 30 Jul 2014 American Institute of Aeronautics and Astronautics (AIAA). https://doi.org/10.2514/6.2014-3658