The Cytomegalovirus gB/MF59 vaccine candidate induces antibodies against an antigenic domain controlling cell-to-cell spread
Journal article
Gomes, A.C., Baraniak, I.A., Lankina, A., Holenya, P., Atkinson, C., Tang, G., Mahungu, T., Kern, F., Griffiths, P.D. and Reeves, M.B. (2023). The Cytomegalovirus gB/MF59 vaccine candidate induces antibodies against an antigenic domain controlling cell-to-cell spread. Nature Communications. 14 (1), pp. 1-12. https://doi.org/10.1038/s41467-023-36683-x
Authors | Gomes, A.C., Baraniak, I.A., Lankina, A., Holenya, P., Atkinson, C., Tang, G., Mahungu, T., Kern, F., Griffiths, P.D. and Reeves, M.B. |
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Abstract | Vaccination against human cytomegalovirus (CMV) infection remains high priority. A recombinant form of a protein essential for CMV entry, glycoprotein B (gB), demonstrated partial protection in a clinical trial (NCT00299260) when delivered with the MF59 adjuvant. Although the antibody titre against gB correlated with protection poor neutralising responses against the 5 known antigenic domains (AD) of gB were evident. Here, we show that vaccination of CMV seronegative patients induces an antibody response against a region of gB we term AD-6. Responses to the polypeptide AD-6 are detected in >70% of vaccine recipients yet in <5% of naturally infected people. An AD-6 antibody binds to gB and to infected cells but not the virion directly. Consistent with this, the AD-6 antibody is non-neutralising but, instead, prevents cell-cell spread of CMV in vitro. The discovery of AD-6 responses has the potential to explain part of the protection mediated by gB vaccines against CMV following transplantation. |
Keywords | Cytomegalovirus Vaccine |
Year | 2023 |
Journal | Nature Communications |
Journal citation | 14 (1), pp. 1-12 |
Publisher | Springer Nature |
ISSN | 2041-1723 |
Digital Object Identifier (DOI) | https://doi.org/10.1038/s41467-023-36683-x |
Publication dates | |
23 Feb 2023 | |
Publication process dates | |
Accepted | 13 Feb 2023 |
Deposited | 03 May 2023 |
Publisher's version | License File Access Level Open |
https://openresearch.lsbu.ac.uk/item/93x39
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