A warfarin-antibiotic drug-drug interaction

Journal article


Feeney, S., Rees, S. and Modha, R.K. (2022). A warfarin-antibiotic drug-drug interaction. Journal of Prescribing Practice. 4 (4), pp. 156-159. https://doi.org/10.12968/jprp.2022.4.4.156SectionsPDF/EPUB
AuthorsFeeney, S., Rees, S. and Modha, R.K.
Abstract

Several groups of antibiotics are known to interact with warfarin, presenting a challenge to the prescriber trying to manage underlying clinical infection, whilst mitigating the risk of coagulopathy. The authors present a case report of a 64- year old warfarinised patient who underwent forefoot surgery and developed a subsequent post-operative infection with combinations of antibiotics, leading to excessive anticoagulation and an adverse drug event. From reviewing both local and national guidance, careful monitoring is mandatory, dosing adjustments and pre-emptive dose reduction might also be needed. Consultation within the wider multi-disciplinary network will be central to decision making and implementing safety netting measures.

Keywordsdrug-drug interaction | warfarin | post-surgical infection
Year2022
JournalJournal of Prescribing Practice
Journal citation4 (4), pp. 156-159
PublisherMark Allen Group
ISSN2631-8385
Digital Object Identifier (DOI)https://doi.org/10.12968/jprp.2022.4.4.156SectionsPDF/EPUB
Publication dates
Print04 Apr 2022
Publication process dates
Accepted25 Feb 2022
Deposited05 May 2022
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Open
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This document is the Accepted Manuscript version of a Published Work that appeared in final form in [JournalTitle], copyright © MA Healthcare, after peer review and technical editing by the publisher. To access the final edited and published work see https://www.magonlinelibrary.com/doi/full/10.12968/jprp.2022.4.4.156

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