A warfarin-antibiotic drug-drug interaction
Journal article
Feeney, S., Rees, S. and Modha, R.K. (2022). A warfarin-antibiotic drug-drug interaction. Journal of Prescribing Practice. 4 (4), pp. 156-159. https://doi.org/10.12968/jprp.2022.4.4.156
Authors | Feeney, S., Rees, S. and Modha, R.K. |
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Abstract | Several groups of antibiotics are known to interact with warfarin, presenting a challenge to the prescriber trying to manage underlying clinical infection, whilst mitigating the risk of coagulopathy. The authors present a case report of a 64- year old warfarinised patient who underwent forefoot surgery and developed a subsequent post-operative infection with combinations of antibiotics, leading to excessive anticoagulation and an adverse drug event. From reviewing both local and national guidance, careful monitoring is mandatory, dosing adjustments and pre-emptive dose reduction might also be needed. Consultation within the wider multi-disciplinary network will be central to decision making and implementing safety netting measures. |
Keywords | drug-drug interaction | warfarin | post-surgical infection |
Year | 2022 |
Journal | Journal of Prescribing Practice |
Journal citation | 4 (4), pp. 156-159 |
Publisher | Mark Allen Group |
ISSN | 2631-8385 |
Digital Object Identifier (DOI) | https://doi.org/10.12968/jprp.2022.4.4.156 |
Publication dates | |
04 Apr 2022 | |
Publication process dates | |
Accepted | 25 Feb 2022 |
Deposited | 05 May 2022 |
Accepted author manuscript | License File Access Level Open |
Additional information | This document is the Accepted Manuscript version of a Published Work that appeared in final form in [JournalTitle], copyright © MA Healthcare, after peer review and technical editing by the publisher. To access the final edited and published work see https://www.magonlinelibrary.com/doi/full/10.12968/jprp.2022.4.4.156 |
https://openresearch.lsbu.ac.uk/item/8zwqy
Download files
Accepted author manuscript
Sep13 Feeney et al warfarin_.docx | ||
License: CC BY 4.0 | ||
File access level: Open |
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