Gabapentin and pregabalin in the pain setting: all you need to know

Journal article


Rees, SM (2018). Gabapentin and pregabalin in the pain setting: all you need to know. Nurse Prescribing. 16 (7). https://doi.org/10.12968/npre.2018.16.7.332
AuthorsRees, SM
Abstract

Abstract The last decade has seen a marked increase in the use of gabapentinoid drugs for pain management. This, in part, reflects the shift from some non-steroidal anti-inflammatory drugs (NSAIDs), as well as issues arising from the protracted use of opioids. More extensive use of gabapentin and pregabalin, has seen the clinical role widen to incorporate a range of unlicensed pain scenarios, as well as increased medicines’ costs. The evidence for efficacy in some pain conditions, namely postherpetic neuralgia and diabetic neuropathic pain, is stronger than for non-neuropathic pain conditions, such as fibromyalgia. Anxiolytic properties, as well as widespread availability, have encouraged recreational misuse, which is associated with doses outside the therapeutic range. Safe use for neuropathic pain (central and peripheral), complex pain, migraine, and the evidence for some non-neuropathic pain conditions will be discussed, as well as the emerging abuse issues. Anti-convulsant interventions will not be covered in this article, nor will use in children

KeywordsGabapentin; pregabalin; neuropathic pain; adjuvant pain
Year2018
JournalNurse Prescribing
Journal citation16 (7)
PublisherMark Allen Healthcare
ISSN1479-9189
Digital Object Identifier (DOI)https://doi.org/10.12968/npre.2018.16.7.332
Publication dates
Print12 Jul 2018
Publication process dates
Deposited02 Jul 2018
Accepted19 Jun 2018
Publisher's version
License
File Access Level
Open
Additional information

This document is the Accepted Manuscript version of a Published Work that appeared in final form in Nurse Prescribing, copyright © MA Healthcare, after peer review and technical editing by the publisher. To access the final edited and published work see http://www.nurseprescribing.com/10.12968/npre.2018.16.7.332

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