The Role of Dynamic Contrast Enhanced MRI perfusion imaging in post treatment surveillance of patients with high grade gliomas

Conference paper


Pigott, L., Mancini, L. and Bisdas, S. (2022). The Role of Dynamic Contrast Enhanced MRI perfusion imaging in post treatment surveillance of patients with high grade gliomas. Siaperas, S, Siapati, E and Chaida, A (ed.) 2nd International Rehabilitation Conference “From Disability to Person and Quality of life”. Athens, Greece 02 - 04 Nov 2022 Beta Medical Publications. pp. 158-165
AuthorsPigott, L., Mancini, L. and Bisdas, S.
TypeConference paper
Abstract

Neuroimaging is a valuable diagnostic and surveillance tool for high-grade gliomas. DCE-MRI is a
perfusion imaging technique, which can quantitatively evaluate tumour biology, concentrating mostly
on the microcirculation and the enhancement patterns in the surrounding tissue. This retrospective
observational study consisted of 48 post-treatment patients having been diagnosed with high-grade
glioma of the brain. Measurements were taken using DCE-MRI at baseline and at 3-month, 6-month,
9-month and 12-month follow-ups. All data was collected from the UCLH electronic health records.
Perfusion maps, BF, AUC, Ktrans, Kep, Ve and Vp, were generated and processed using commercially
available software. Eight survival analysis models differentiated progression from stable disease and
pseudo-progression from true progression, across the 6- and 12-month timepoints. Models 1 through
4 assessed disease progression based on the initial baseline scan, while models 5 through 8 assessed
progression based on the baseline and the 3-month DCE-MRI scan. All survival analysis models were
statistically significant with high sensitivity and specificity. The starting hypotheses were verified.

Keywords Glioma, Brain Cancer, DCE-MRI, Advanced Neuroimaging.
Year2022
PublisherBeta Medical Publications
Web address (URL)https://rehabconf.mitropolitiko.edu.gr/wp-content/uploads/2023/11/REHAB_E-BOOK_WEB_BODY-COVER-17x24_2023.11_LR.pdf
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License
File Access Level
Open
Publication dates
Print02 Nov 2022
Publication process dates
Accepted09 Apr 2022
Deposited08 Dec 2023
Book titleRehab 2022:Proceedings of the 2nd International Rehabilitation Conference “From Disability to Person and Quality of life”
Page range158-165
EditorsSiaperas, S, Siapati, E and Chaida, A
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https://openresearch.lsbu.ac.uk/item/959ww

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