Is there cardiac autonomic dysfunction in children and adolescents with exercise-induced bronchospasm?

Journal article

Chaves Quirino, Polyanna Guerra, Rizzo, José Ângelo, Hunter, Steve, de Albuquerque Rodrigues Filho, Edil, Sarinho, Emanuel, de Almeida Santos, Camila Matias, Medeiros, Decio, Costa, Emilia Chagas, Silva, Alexandre Sérgio, Farah, Breno Quintella and de Correia Junior, M. (2023). Is there cardiac autonomic dysfunction in children and adolescents with exercise-induced bronchospasm? Expert Review of Respiratory Medicine. https://doi.org/10.1080/17476348.2023.2265819
AuthorsChaves Quirino, Polyanna Guerra, Rizzo, José Ângelo, Hunter, Steve, de Albuquerque Rodrigues Filho, Edil, Sarinho, Emanuel, de Almeida Santos, Camila Matias, Medeiros, Decio, Costa, Emilia Chagas, Silva, Alexandre Sérgio, Farah, Breno Quintella and de Correia Junior, M.
Abstract

The pulmonary impairment in patients with bronchoconstriction induced by eucapnic voluntary hyperpnea(EVH) goes beyond the respiratory system, also impairing autonomic nervous modulation. This study aimed to evaluate the behavior of cardiac autonomic modulation in young asthmatics with and without EIB after the EVH test.

Research design and methods
A cross-sectional study design using 54 asthmatics(51.9% female), aged between 10 and 19 years, investigated with the EVH test. Forced expiratory volume in one second(FEV1) was measured at 5, 10, 15, and 30 min after EVH. Heart rate variability(HRV) measures of time were assessed pre and 30 min-post EVH. The diagnosis of Exercise-Induced bronchoconstriction with underlying clinical asthma(EIBA) was confirmed by a fall in FEV1 ≥10% compared to baseline.

Results
Thirty(55.5%) asthmatics had EIBA. Subjects with EIBA have reduced mean of the R-R intervals in relation to baseline until 15 minutes after EVH. Individuals without EIBA had increased parasympathetic activity compared to baseline(rMSSD) from 5 min after EVH(p < 0.05). This parasympathetic activity increase in relation to baseline was seen in individuals with EIBA after 25 minutes (rMSSD = 49.9 ± 5.3 vs 63.5 ± 7.2, p < 0.05).

Conclusion
Young asthmatics with EIBA present a delay in the increase of the parasympathetic component after EVH when compared to asthmatics without EIBA.

KeywordsPublic Health, Environmental and Occupational Health; Pulmonary and Respiratory Medicine; Immunology and Allergy
Year2023
JournalExpert Review of Respiratory Medicine
PublisherInforma UK Limited
ISSN1747-6348
1747-6356
Digital Object Identifier (DOI)https://doi.org/10.1080/17476348.2023.2265819
Publication dates
Online05 Oct 2023
Publication process dates
Accepted28 Sep 2023
Deposited15 Jan 2024
Accepted author manuscript
License
File Access Level
Open
Page range1-9
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