Noble Metal Nanoparticle Biosensors: From Fundamental Studies toward Point-of-Care Diagnostics

Journal article


Geng, H., Vilms Pedersen, S., Ma, Y., Haghighi, T., Dai, H., Howes, P. and Stevens, M. (2022). Noble Metal Nanoparticle Biosensors: From Fundamental Studies toward Point-of-Care Diagnostics. Accounts of Chemical Research. 55 (5), pp. 593-604. https://doi.org/10.1021/acs.accounts.1c00598
AuthorsGeng, H., Vilms Pedersen, S., Ma, Y., Haghighi, T., Dai, H., Howes, P. and Stevens, M.
AbstractConspectusNoble metal nanoparticles (NMNPs) have become firmly established as effective agents to detect various biomolecules with extremely high sensitivity. This ability stems from the collective oscillation of free electrons and extremely large electric field enhancement under exposure to light, leading to various light-matter interactions such as localized surface plasmon resonance (LSPR) and surface-enhanced Raman scattering. A remarkable feature of NMNPs is their customizability by mechanisms such as particle etching, growth, and aggregation/dispersion, yielding distinct color changes and excellent opportunities for colorimetric biosensing in user-friendly assays and devices. They are readily functionalized with a large variety of capping agents and biomolecules, with resultant bioconjugates often possessing excellent biocompatibility, which can be used to quantitatively detect analytes from physiological fluids. Furthermore, they can possess excellent catalytic properties that can achieve significant signal amplification through mechanisms such as the catalytic transformation of colorless substrates to colored reporters. The various excellent attributes of NMNP biosensors have put them in the spotlight for developing high-performance in vitro diagnostic (IVD) devices that are particularly well-suited to mitigate the societal threat that infectious diseases pose. This threat continues to dominate the global health care landscape, claiming millions of lives annually. NMNP IVDs possess the potential to sensitively detect infections even at very early stages with affordable and field-deployable devices, which will be key to strengthening infectious disease management. This has been the major focal point of current research, with a view to new avenues for early multiplexed detection of infectious diseases with portable devices such as smartphones, especially in resource-limited settings.In this Account, we provide an overview of our original inspiration and efforts in NMNP-based assay development, together with some more sophisticated IVD assays by ourselves and many others. Our work in the area has led to our recent efforts in developing IVDs for high-profile infectious diseases, including Ebola and HIV. We emphasize that integration with digital platforms represents an opportunity to establish and efficiently manage widespread testing, tracking, epidemiological intelligence, and data sharing backed by community participation. We highlight how digital technologies can address the limitations of conventional diagnostic technologies at the point of care (POC) and how they may be used to abate and contain the spread of infectious diseases. Finally, we focus on more recent integrations of noble metal nanoparticles with Raman spectroscopy for accurate, noninvasive POC diagnostics with improved sensitivity and specificity.
KeywordsGeneral Medicine; General Chemistry
Year2022
JournalAccounts of Chemical Research
Journal citation55 (5), pp. 593-604
PublisherAmerican Chemical Society (ACS)
ISSN0001-4842
1520-4898
Digital Object Identifier (DOI)https://doi.org/10.1021/acs.accounts.1c00598
Web address (URL)https://pubs.acs.org/doi/10.1021/acs.accounts.1c00598
Funder/ClientEngineering and Physical Sciences Research Council
Royal Academy of Engineering
Det Frie Forskningsr??d
China Postdoctoral Science Foundation
H2020 Marie Skłodowska-Curie Actions
Wellcome Trust
FP7 Ideas: European Research Council
National Natural Science Foundation of China
H2020 European Research Council
Publication dates
Online09 Feb 2022
Print01 Mar 2022
Publication process dates
Accepted06 Dec 2021
Deposited04 May 2022
Accepted author manuscript
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Open
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This document is the Accepted Manuscript version of a Published Work that appeared in final form in Accounts of Chemical Research, copyright © 2022 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/doi/10.1021/acs.accounts.1c00598

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