When the brain, but not the person, remembers: Cortical reinstatement is modulated by retrieval goal in developmental amnesia.

Journal article


Elward, R.L, Rugg, M.D and Vargha-Khadem, F. (2021). When the brain, but not the person, remembers: Cortical reinstatement is modulated by retrieval goal in developmental amnesia. Neuropsychologia. https://doi.org/10.1016/j.neuropsychologia.2021.107788
AuthorsElward, R.L, Rugg, M.D and Vargha-Khadem, F.
AbstractDevelopmental amnesia (DA) is associated with early hippocampal damage and subsequent episodic amnesia emerging in childhood alongside age-appropriate development of semantic knowledge. We employed fMRI to assess whether patients with DA show evidence of 'cortical reinstatement', a neural correlate of episodic memory, despite their amnesia. At study, 23 participants (5 patients) were presented with words overlaid on a scene or a scrambled image for later recognition. Scene reinstatement was indexed by scene memory effects (greater activity for previously presented words paired with a scene rather than scrambled images) that overlapped with scene perception effects. Patients with DA demonstrated scene reinstatement effects in the parahippocampal and retrosplenial cortex that were equivalent to those shown by healthy controls. Behaviourally, however, patients with DA showed markedly impaired scene memory. The data indicate that reinstatement can occur despite hippocampal damage, but that cortical reinstatement is insufficient to support accurate memory performance. Furthermore, scene reinstatement effects were diminished during a retrieval task in which scene information was not relevant for accurate responding, indicating that strategic mnemonic processes operate normally in DA. The data suggest that cortical reinstatement of trial-specific contextual information is decoupled from the experience of recollection in the presence of severe hippocampal atrophy. [Abstract copyright: Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved.]
KeywordsMemory Retrieval; Recollection; Scene Reinstatement; Strategic-Retrieval; fMRI
Year2021
JournalNeuropsychologia
PublisherElsevier
ISSN1873-3514
Digital Object Identifier (DOI)https://doi.org/10.1016/j.neuropsychologia.2021.107788
Publication dates
Online12 Feb 2021
Publication process dates
Accepted08 Feb 2021
Deposited17 Mar 2021
Publisher's version
License
File Access Level
Open
Page range107788
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