When the brain, but not the person, remembers: Cortical reinstatement is modulated by retrieval goal in developmental amnesia.

Journal article


Elward, R.L, Rugg, M.D and Vargha-Khadem, F. (2021). When the brain, but not the person, remembers: Cortical reinstatement is modulated by retrieval goal in developmental amnesia. Neuropsychologia. https://doi.org/10.1016/j.neuropsychologia.2021.107788
AuthorsElward, R.L, Rugg, M.D and Vargha-Khadem, F.
AbstractDevelopmental amnesia (DA) is associated with early hippocampal damage and subsequent episodic amnesia emerging in childhood alongside age-appropriate development of semantic knowledge. We employed fMRI to assess whether patients with DA show evidence of 'cortical reinstatement', a neural correlate of episodic memory, despite their amnesia. At study, 23 participants (5 patients) were presented with words overlaid on a scene or a scrambled image for later recognition. Scene reinstatement was indexed by scene memory effects (greater activity for previously presented words paired with a scene rather than scrambled images) that overlapped with scene perception effects. Patients with DA demonstrated scene reinstatement effects in the parahippocampal and retrosplenial cortex that were equivalent to those shown by healthy controls. Behaviourally, however, patients with DA showed markedly impaired scene memory. The data indicate that reinstatement can occur despite hippocampal damage, but that cortical reinstatement is insufficient to support accurate memory performance. Furthermore, scene reinstatement effects were diminished during a retrieval task in which scene information was not relevant for accurate responding, indicating that strategic mnemonic processes operate normally in DA. The data suggest that cortical reinstatement of trial-specific contextual information is decoupled from the experience of recollection in the presence of severe hippocampal atrophy. [Abstract copyright: Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved.]
KeywordsMemory Retrieval; Recollection; Scene Reinstatement; Strategic-Retrieval; fMRI
Year2021
JournalNeuropsychologia
PublisherElsevier
ISSN1873-3514
Digital Object Identifier (DOI)https://doi.org/10.1016/j.neuropsychologia.2021.107788
Publication dates
Online12 Feb 2021
Publication process dates
Accepted08 Feb 2021
Deposited17 Mar 2021
Publisher's version
License
File Access Level
Open
Page range107788
Permalink -

https://openresearch.lsbu.ac.uk/item/8w561

Download files


Publisher's version
1-s2.0-S0028393221000397-main.pdf
License: CC BY-NC-ND 4.0
File access level: Open

  • 116
    total views
  • 81
    total downloads
  • 1
    views this month
  • 2
    downloads this month

Export as

Related outputs

Embedding student-centred active learning environment with upside-down pedagogies in teaching practice: What works for psychology?
Premkumar, P., Churchill, T., Elward, R. and Alford,A. (2024). Embedding student-centred active learning environment with upside-down pedagogies in teaching practice: What works for psychology? Psychology Teaching Review. 30 (1), pp. 7-31. https://doi.org/10.53841/bpsptr.2024.30.1.7
Using recognition testing to support semantic learning in developmental amnesia
Elward, R., Limond, J., Chareyron, L.J., Ethapemi, J. and Vargha-Khadem, F. (2023). Using recognition testing to support semantic learning in developmental amnesia. Neuropsychological Rehabilitation. https://doi.org/10.1080/09602011.2023.2275825
Effects of age on goal-dependent modulation of episodic memory retrieval.
Srokova, S., Hill, P.F., Elward, R.L. and Rugg, M.D. (2021). Effects of age on goal-dependent modulation of episodic memory retrieval. Neurobiology of aging. 102, pp. 73-88. https://doi.org/10.1016/j.neurobiolaging.2021.02.004
Functional magnetic resonance imaging.
Liégeois, F. and Elward, R. (2020). Functional magnetic resonance imaging. Handbook of clinical neurology. 174, pp. 265-275. https://doi.org/10.1016/B978-0-444-64148-9.00019-3
Little evidence for fast mapping in adults with developmental amnesia.
Elward, R., Dzieciol A.M. and Vargha-Khadem, F. (2019). Little evidence for fast mapping in adults with developmental amnesia. Journal of Cognitive Neuroscience. 10 (4). https://doi.org/10.1080/17588928.2019.1593123
Semantic memory in developmental amnesia
Elward, R. and Vargha-Khadem, F. (2018). Semantic memory in developmental amnesia. Neuroscience Letters. 680, pp. 23-30.
Dissociation between the neural correlates of recollection and familiarity in the striatum and hippocampus: Across-study convergence
King, D.R., Chastelaine, M.D., Elward, R., Wang, T.H. and Rugg, M.D. (2017). Dissociation between the neural correlates of recollection and familiarity in the striatum and hippocampus: Across-study convergence. Behavioural Brain Research. 354, pp. 1-7. https://doi.org/10.1016/j.bbr.2017.07.031
Motivated Memories: Effects of reward and recollection in the core recollection network and beyond
Elward, R., Vilberg, K.L. and Rugg, M.D. (2015). Motivated Memories: Effects of reward and recollection in the core recollection network and beyond. Cerebral Cortex. 25 (9), pp. 3159-3166. https://doi.org/10.1093/cercor/bhu109
Recollection-Related Increases in Functional Connectivity Predict Individual Differences in Memory Accuracy
King, D.R., Chastelaine, M., Elward, R., Wang, T.H. and Rugg, M.D. (2015). Recollection-Related Increases in Functional Connectivity Predict Individual Differences in Memory Accuracy. Journal of Neuroscience. 35 (4), pp. 1763-1772. https://doi.org/10.1523/JNEUROSCI.3219-14.2015
Retrieval Goal Modulates Memory for Context
Elward, R. and Rugg, M.D. (2015). Retrieval Goal Modulates Memory for Context. Journal of Cognitive Neuroscience. 27 (12). https://doi.org/10.1162/jocn_a_00878
The role of working memory capacity in the control of recollection
Elward, R., Evans, L.H. and Wilding, E.L. (2013). The role of working memory capacity in the control of recollection. Cortex. 46 (6), pp. 1452-1462. https://doi.org/10.1016/j.cortex.2012.07.003
Working memory capacity is related to variations in the magnitude of an electrophysiological marker of recollection
Elward, R. and Wilding, E.L. (2010). Working memory capacity is related to variations in the magnitude of an electrophysiological marker of recollection. Brain Research. 1342, pp. 55-62. https://doi.org/10.1016/j.brainres.2010.04.040
Cross-modal face identity aftereffects and their relation to priming
Hills, P.J., Elward, R. and Lewis, M.B. (2010). Cross-modal face identity aftereffects and their relation to priming. Journal of Experimental Psychology: Human Perception and Performance. 36 (4), pp. 876-891. https://doi.org/10.1037/a0018731
Reduced specificity of autobiographical memory and depression: The role of executive control
Dalgleish, T., Williams, J.M.G., Golden, A-M. J., Perkins, N., Barrett, L.F., Barnard, P.J., Au Yeung, C., Murphy, V., Elward, R., Tchanturia, K. and Watkins, E. (2007). Reduced specificity of autobiographical memory and depression: The role of executive control. Journal of Experimental Psychology: General. 136 (1), p. 23/42. https://doi.org/10.1037/0096-3445.136.1.23