Pharmacologic modulation of hand pain in osteoarthritis: A double-blind placebo-controlled functional magnetic resonance imaging study using naproxen

Journal article


Sanders, D, Krause, K, O'Muircheartaigh, J, Thacker, M., Huggins, JP, Vennart, W, Massat, NJ, Choy, E, Williams, SCR and Howard, MA (2015). Pharmacologic modulation of hand pain in osteoarthritis: A double-blind placebo-controlled functional magnetic resonance imaging study using naproxen. Arthritis and Rheumatology. 67 (3), pp. 741-751. https://doi.org/10.1002/art.38987
AuthorsSanders, D, Krause, K, O'Muircheartaigh, J, Thacker, M., Huggins, JP, Vennart, W, Massat, NJ, Choy, E, Williams, SCR and Howard, MA
Abstract

Objective.In an attempt to shed light on management of chronic pain conditions, there has long been a desire to complement behavioral measures of pain perception with measures of underlying brain mechanisms. Using functional magnetic resonance imaging(fMRI), we undertook this study to investigate changes in brain activity following the administration of naproxen or placebo in patients with pain related to osteoarthritis (OA) of the carpometacarpal (CMC)joint.
Methods.A placebo-controlled, double-blind,2-period crossover study was performed in 19 individuals with painful OA of the CMC joint of the right hand.Following placebo or naproxen treatment periods, a functionally relevant task was performed, and behavioral measures of the pain experience were collected in identical fMRI examinations. Voxelwise and a priori region of interest analyses were performed to detect between period differences in brain activity.
Results.Significant reductions in brain activity following treatment with naproxen, compared to placebo, were observed in brain regions commonly associated with pain perception, including the bilateral primary somatosensory cortex, thalamus, and amygdala.Significant relationships between changes in perceived pain intensity and changes in brain activity were also observed in brain regions previously associated with pain intensity.
Conclusion.This study demonstrates the sensitivity of fMRI to detect the mechanisms underlying treatments of known efficacy. The data illustrate the enticing potential of fMRI as an adjunct to self-report for detecting early signals of efficacy of novel therapies,both pharmacologic and nonpharmacologic, in small numbers of individuals with persistent pain.

Year2015
JournalArthritis and Rheumatology
Journal citation67 (3), pp. 741-751
ISSN2326-5191
Digital Object Identifier (DOI)https://doi.org/10.1002/art.38987
Publication dates
Print01 Mar 2015
Publication process dates
Deposited25 Jun 2019
Accepted04 Dec 2014
Publisher's version
License
File Access Level
Open
Permalink -

https://openresearch.lsbu.ac.uk/item/8770q

Download files


Publisher's version
Sanders_et_al-2015-Arthritis_&_Rheumatology.pdf
License: CC BY-NC 4.0
File access level: Open

  • 37
    total views
  • 53
    total downloads
  • 0
    views this month
  • 0
    downloads this month

Export as

Related outputs

Cervical spine radiculopathy epidemiology: A systematic review
Mansfield, M., Smith, T., Spahr, Nicolas and Thacker, Mick (2020). Cervical spine radiculopathy epidemiology: A systematic review. Musculoskeletal Care. 18 (4), pp. 555-567. https://doi.org/10.1002/msc.1498
Cervical Spine Radiculopathy Epidemiology: Systematic Review
Mansfield, M., Smith, T, Spahr, N and Thacker, M. (2020). Cervical Spine Radiculopathy Epidemiology: Systematic Review. London Doctoral Academy Postgraduate Research Summer School 2020. Online 06 - 09 Jul 2020 London South Bank University, School of Health and Social Care.
Gait-initiation onset estimation during sit-towalk: Recommended methods suitable for healthy individuals and ambulatory community-dwelling stroke survivors
Jones, GD, James, D., Thacker, M., Perry, R and Green, DA (2019). Gait-initiation onset estimation during sit-towalk: Recommended methods suitable for healthy individuals and ambulatory community-dwelling stroke survivors. PLoS ONE. 14 (5). https://doi.org/10.1371/journal.pone.0217563
Somatosensory Profiling in Cervical Spine and Radicular Pain
Mansfield, M. and Thacker, M. (2019). Somatosensory Profiling in Cervical Spine and Radicular Pain. Physio First Conference 2019. Nottingham, UK 05 - 06 Apr 2019 Physio First.
Gait-Initiation Onset Estimation During Sit-to-Walk Comparing Healthy Individuals and Ambulatory Community-Dwelling Stroke Survivors
Jones, GD, James, DC, Thacker, M, Perry, R and Green, DA (2019). Gait-Initiation Onset Estimation During Sit-to-Walk Comparing Healthy Individuals and Ambulatory Community-Dwelling Stroke Survivors. https://doi.org/10.18744/LSBU.002933
Physical activity interventions are delivered consistently across hospitalized older adults but multimorbidity is associated with poorer rehabilitation outcomes: A population-based cohort study
Jones, J, Jones, GD, Thacker, M and Faithfull, S (2017). Physical activity interventions are delivered consistently across hospitalized older adults but multimorbidity is associated with poorer rehabilitation outcomes: A population-based cohort study. Journal of Evaluation in Clinical Practice. 23 (6), pp. 1469-1477. https://doi.org/10.1111/jep.12833
Pain: A Statistical Account
Tabor, A, Thacker, M., Moseley, GL and K├Ârding, KP (2017). Pain: A Statistical Account. PLoS Computational Biology. 13 (1), pp. e1005142-e1005142. https://doi.org/10.1371/journal.pcbi.1005142
The close proximity of threat: Altered distance perception in the anticipation of pain
Tabor, A, Catley, MJ, Gandevia, SC, Thacker, M., Spence, C and Moseley, GL (2015). The close proximity of threat: Altered distance perception in the anticipation of pain. Frontiers in Psychology. 6 (MAY). https://doi.org/10.3389/fpsyg.2015.00626
Quantifying the test-retest reliability of cerebral blood flow measurements in a clinical model of on-going post-surgical pain: A study using pseudo-continuous arterial spin labelling
Hodkinson, DJ, Krause, K, Khawaja, N, Renton, TF, Huggins, JP, Vennart, W, Thacker, M., Mehta, MA, Zelaya, FO, Williams, SCR and Howard, MA (2013). Quantifying the test-retest reliability of cerebral blood flow measurements in a clinical model of on-going post-surgical pain: A study using pseudo-continuous arterial spin labelling. NeuroImage: Clinical. 3, pp. 301-310. https://doi.org/10.1016/j.nicl.2013.09.004