A cyclosporine derivative is a substrate of the oligopeptide transporter PepT1

Journal article


Bailey, PD, Foley, D, Bermudez, I and Meredith, D (2016). A cyclosporine derivative is a substrate of the oligopeptide transporter PepT1. MedChemComm. 7 (5), pp. 999 - 1002.
AuthorsBailey, PD, Foley, D, Bermudez, I and Meredith, D
Abstract

© The Royal Society of Chemistry 2016.The mammalian proton-coupled oligopeptide transporter PepT1 is recognised as an important route of oral drug delivery. Peptide-based compounds offer great potential as drugs but their application is limited by poor membrane permeability, amongst other challenges. Using cyclosporin A as a proof-of-concept, we demonstrate for the first time that peptidic molecules over 1000 Da in size can be targeted towards and transported by PepT1.

Year2016
JournalMedChemComm
Journal citation7 (5), pp. 999 - 1002
PublisherRoyal Society of Chemistry
ISSN2040-2511
Digital Object Identifier (DOI)doi:10.1039/c5md00575b
Publication dates
Print15 Mar 2016
Publication process dates
Deposited10 Aug 2016
Accepted12 Mar 2016
Accepted author manuscript
License
CC BY-NC-ND 4.0
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https://openresearch.lsbu.ac.uk/item/874vq

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