A cyclosporine derivative is a substrate of the oligopeptide transporter PepT1
Bailey, PD, Foley, D, Bermudez, I and Meredith, D (2016). A cyclosporine derivative is a substrate of the oligopeptide transporter PepT1. MedChemComm. 7 (5), pp. 999 - 1002.
|Authors||Bailey, PD, Foley, D, Bermudez, I and Meredith, D|
© The Royal Society of Chemistry 2016.The mammalian proton-coupled oligopeptide transporter PepT1 is recognised as an important route of oral drug delivery. Peptide-based compounds offer great potential as drugs but their application is limited by poor membrane permeability, amongst other challenges. Using cyclosporin A as a proof-of-concept, we demonstrate for the first time that peptidic molecules over 1000 Da in size can be targeted towards and transported by PepT1.
|Journal citation||7 (5), pp. 999 - 1002|
|Publisher||Royal Society of Chemistry|
|Digital Object Identifier (DOI)||doi:10.1039/c5md00575b|
|15 Mar 2016|
|Publication process dates|
|Deposited||10 Aug 2016|
|Accepted||12 Mar 2016|
|Accepted author manuscript|
CC BY-NC-ND 4.0
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