Stress-Relaxation and Cyclic Behavior of Human Carotid Plaque Tissue

Journal article


Wang, J. (2020). Stress-Relaxation and Cyclic Behavior of Human Carotid Plaque Tissue. Frontiers in Bioengineering and Biotechnology. 8. https://doi.org/10.3389/fbioe.2020.00060
AuthorsWang, J.
Abstract

Atherosclerotic plaque rupture is a catastrophic event that contributes to mortality and long-term disability. A better understanding of the plaque mechanical behavior is essential for the identification of vulnerable plaques pre-rupture. Plaque is subjected to a natural dynamic mechanical environment under hemodynamic loading. Therefore, it is important to understand the mechanical response of plaque tissue under cyclic loading conditions. Moreover, experimental data of such mechanical properties are fundamental for more clinically relevant biomechanical modeling and numerical simulations for risk stratification. This study aims to experimentally and numerically characterize the stress-relaxation and cyclic mechanical behavior of carotid plaque tissue. Instron microtester equipped with a custom-developed setup was used for the experiments. Carotid plaque samples excised at endarterectomy were subjected to uniaxial tensile, stress-relaxation, and cyclic loading protocols. Thirty percent of the underlying load level obtained from the uniaxial tensile test results was used to determine the change in mechanical properties of the tissue over time under a controlled testing environment (Control tests). The stress-relaxation test data was used to calibrate the hyperelastic (neo-Hookean, Ogden, Yeoh) and linear viscoelastic (Prony series) material parameters. The normalized relaxation force increased initially and slowly stabilized toward the end of relaxation phase, highlighting the viscoelastic behavior. During the cyclic tests, there was a decrease in the peak force as a function of the cycle number indicating mechanical distension due to repeated loading that varied with different frequencies. The material also accumulated residual deformation, which increased with the cycle number. This trend showed softening behavior of the samples. The results of this preliminary study provide an enhanced understanding of in vivo stress-relaxation and cyclic behavior of the human atherosclerotic plaque tissue.

Year2020
JournalFrontiers in Bioengineering and Biotechnology
Journal citation8
PublisherFrontiers Media
ISSN2296-4185
Digital Object Identifier (DOI)https://doi.org/10.3389/fbioe.2020.00060
Publication dates
Print11 Feb 2020
Publication process dates
Deposited08 Jan 2024
Publisher's version
License
File Access Level
Open
Permalink -

https://openresearch.lsbu.ac.uk/item/95zq6

Download files


Publisher's version
fbioe-08-00060.pdf
License: CC BY 4.0
File access level: Open

  • 14
    total views
  • 3
    total downloads
  • 0
    views this month
  • 0
    downloads this month

Export as

Related outputs

Constrained estimation of intracranial aneurysm surface deformation using 4D-CTA
Xie, H., Wu, H., Wang, J., Mendieta, J.B., Yu, H., Xiang, Y., Anbananthan, H., Zhang, J., Zhao, H., Zhu, Z., Huang, Q., Fang, R., Zhu, C. and Li, Z. (2024). Constrained estimation of intracranial aneurysm surface deformation using 4D-CTA. Computer Methods and Programs in Biomedicine. 244, p. 107975. https://doi.org/10.1016/j.cmpb.2023.107975
Reproducibility of the computational fluid dynamic analysis of a cerebral aneurysm monitored over a decade
Paritala, P.K., Anbananthan, H., Hautaniemi, J., Smith, M., George, A., Allenby, M., Mendieta, J.B., Wang, J., Maclachlan, L., Liang, E., Prior, M., Yarlagadda, P.K.D.V., Winter, C. and Li, Z. (2023). Reproducibility of the computational fluid dynamic analysis of a cerebral aneurysm monitored over a decade. Scientific Reports. 13, p. 219. https://doi.org/10.1038/s41598-022-27354-w
MRI-based mechanical analysis of carotid atherosclerotic plaque using a material-property-mapping approach: A material-property-mapping method for plaque stress analysis
Mendieta, J.B., Fontanarosa, D., Wang, J., Paritala. P.K., Muller, J., Lloyd, T. and Li, Z. (2023). MRI-based mechanical analysis of carotid atherosclerotic plaque using a material-property-mapping approach: A material-property-mapping method for plaque stress analysis. Computer Methods and Programs in Biomedicine. 231, p. 107417. https://doi.org/10.1016/j.cmpb.2023.107417
Impact of cyclic bending on coronary hemodynamics
Wang, J., Fang, R., Wu, H., Xiang, Y., Mendieta, J.B., Paritala, P.K., Fan, Z., Anbananthan, H., Catano, J.A.A., Raffel, O.C. and Li, Z. (2023). Impact of cyclic bending on coronary hemodynamics. Biomechanics and Modeling in Mechanobiology. 22, pp. 729-738. https://doi.org/10.1007/s10237-022-01677-z
Computer-assisted pre-operative automatic segmentation and registration tool for malunited radius osteotomy: A proof-of-concept study
Wang, J., Zietal, R., Arase, A., Couzens, G., Pivonka, P. and Fontanarosa, D. (2023). Computer-assisted pre-operative automatic segmentation and registration tool for malunited radius osteotomy: A proof-of-concept study. Results in Engineering. 19, p. 101295. https://doi.org/10.1016/j.rineng.2023.101295
Shape dependent protein‐induced stabilization of gold nanoparticles: From a protein corona perspective
Tukova, A., Nie, Y., Tavakkoli Yaraki, M., Tran, N.T., Wang, J., Rodger, A., Gu, Y. and Wang, Y. (2023). Shape dependent protein‐induced stabilization of gold nanoparticles: From a protein corona perspective. Aggregate. 4 (4), p. e323. https://doi.org/10.1002/agt2.323
Optical coherence elastography based on inverse compositional Gauss-Newton digital volume correlation with second-order shape function
Wu, H., Wang, J., Catano, J.A.A., Sun, C. and Li, Z. (2022). Optical coherence elastography based on inverse compositional Gauss-Newton digital volume correlation with second-order shape function. Optics Express. 30 (23), pp. 41954-41968. https://doi.org/10.1364/OE.473898
Atomistic Investigation of Titanium Carbide Ti8C5 under Impact Loading
Xia, K., Zhan, H., Shao, J., Wang, J., Zheng, Z., Zhang, X. and Li, Z. (2022). Atomistic Investigation of Titanium Carbide Ti8C5 under Impact Loading. Metals. 12 (11), p. 1989. https://doi.org/10.3390/met12111989
The Need to Shift from Morphological to Structural Assessment for Carotid Plaque Vulnerability
Xiang, Y., Huang, X., Mendieta, J.B., Wang, J., Paritala, P.K., Lloyd, T. and Li, Z. (2022). The Need to Shift from Morphological to Structural Assessment for Carotid Plaque Vulnerability. Biomedicines. 10 (12), p. 3038. https://doi.org/10.3390/biomedicines10123038
Computational Fluid Dynamics Simulations at Micro-Scale Stenosis for Microfluidic Thrombosis Model Characterization
Zhao, Y.C., Vatankhah, P., Goh, T., Wang, J., Chen, X.V., Kashani, M.N., Zheng, K., Li, Z. and Ju, L.A. (2021). Computational Fluid Dynamics Simulations at Micro-Scale Stenosis for Microfluidic Thrombosis Model Characterization. Molecular & Cellular Biomechanics. 18 (1), pp. 1-10. https://doi.org/10.32604/mcb.2021.012598
Optical coherence tomography-based patient-specific coronary artery reconstruction and fluid–structure interaction simulation
Wang, J., Paritala, P.K., Mendieta, J.B., Komori, Y., Raffel, O.C., Gu, Y. and Li, Z. (2020). Optical coherence tomography-based patient-specific coronary artery reconstruction and fluid–structure interaction simulation. Biomechanics and Modeling in Mechanobiology. 19, pp. 7-20. https://doi.org/10.1007/s10237-019-01191-9
Characterization of the Atherosclerotic Plaque Tissue
Paritala, P.K., Yarlagadda, T., Mendieta, J.B., Wang, J., Gu, Y., Li, Z. and Yarlagadda, P.K.D.V. (2020). Characterization of the Atherosclerotic Plaque Tissue. Advanced Materials Letters. 11 (5). https://doi.org/10.5185/amlett.2020.051507
The importance of blood rheology in patient-specific computational fluid dynamics simulation of stenotic carotid arteries
Mendieta, J.B., Fontarosa, D., Wang, J., Paritala, P.K., McGahan, T., Lloyd, T. and Li, Z. (2020). The importance of blood rheology in patient-specific computational fluid dynamics simulation of stenotic carotid arteries. Biomechanics and Modeling in Mechanobiology. 19, pp. 1477-1490. https://doi.org/10.1007/s10237-019-01282-7
Automated classification of coronary plaque calcification in OCT pullbacks with 3D deep neural networks
He, C., Wang, J., Yin, Y. and Li, Z. (2020). Automated classification of coronary plaque calcification in OCT pullbacks with 3D deep neural networks. Journal of Biomedical Optics. 26 (9), p. 095003. https://doi.org/10.1117/1.JBO.25.9.095003
Atherosclerotic Plaque Tissue Characterization: An OCT-Based Machine Learning Algorithm With ex vivo Validation
He, C., Li, Z., Wang, J., Huang, Y., Yin, Y. and Li, Z. (2020). Atherosclerotic Plaque Tissue Characterization: An OCT-Based Machine Learning Algorithm With ex vivo Validation. Frontiers in Bioengineering and Biotechnology. 8. https://doi.org/10.3389/fbioe.2020.00749
Carotid Bifurcation With Tandem Stenosis—A Patient-Specific Case Study Combined in vivo Imaging, in vitro Histology and in silico Simulation
Wang, J., Paritala, P.K., Mendieta, J.B., Gu, Y., Raffel, O.C., McGahan, T., Lloyd, T. and Li, Z. (2019). Carotid Bifurcation With Tandem Stenosis—A Patient-Specific Case Study Combined in vivo Imaging, in vitro Histology and in silico Simulation. Frontiers in Bioengineering and Biotechnology. 7. https://doi.org/10.3389/fbioe.2019.00349
Prediction of atherosclerotic plaque life – Perceptions from fatigue analysis
Paritala, P.K., Yarlagadda, T., Wang, J., Gu, Y.T. and Li, Z. (2019). Prediction of atherosclerotic plaque life – Perceptions from fatigue analysis. Procedia Manufacturing. 30, pp. 522-529. https://doi.org/10.1016/j.promfg.2019.02.073
3D-printing based Transducer Holder for Robotic Assisted Ultrasound Guided HIFU
Wang, J., Xu, X., Huang, Z. and Melzer, A. (2019). 3D-printing based Transducer Holder for Robotic Assisted Ultrasound Guided HIFU. Procedia Manufacturing. 30, pp. 3-10. https://doi.org/10.1016/j.promfg.2019.02.002
Numerical investigation of atherosclerotic plaque rupture using optical coherence tomography imaging and XFEM
Paritala, P.K., Yarlagadda, P.K.D.V., Wang, J., Gu, Y. and Li, Z. (2018). Numerical investigation of atherosclerotic plaque rupture using optical coherence tomography imaging and XFEM. Engineering Fracture Mechanics. 204, pp. 531-541. https://doi.org/10.1016/j.engfracmech.2018.11.002
Intravascular Optical Coherence Tomography Image Segmentation Based on Support Vector Machine Algorithm
Huang, Y., He, C., Wang, J., Miao, Y., Zhu, T., Zhou, P. and Li, Z. (2018). Intravascular Optical Coherence Tomography Image Segmentation Based on Support Vector Machine Algorithm. Molecular & Cellular Biomechanics. 15 (2), pp. 117-125. https://doi.org/10.3970/mcb.2018.02478
The Correlation Between Texture Features and Fibrous Cap Thickness of Lipid-Rich Atheroma Based on Optical Coherence Tomography Imaging
He, C., Wang, J., Huang, Y., Zhu, T., Miao. Y. and Li, Z. (2016). The Correlation Between Texture Features and Fibrous Cap Thickness of Lipid-Rich Atheroma Based on Optical Coherence Tomography Imaging. Molecular & Cellular Biomechanics. 13 (1), pp. 23-36. https://doi.org/10.3970/mcb.2016.013.027
Thiel soft embalmed Porcine Kidney Perfusion Model for focused ultrasound therapy
Wang, J., Xiao, X., Duncan, R., Karakitsios, I., Huang, Z., Mcleod, H. and Melzer, A. (2015). Thiel soft embalmed Porcine Kidney Perfusion Model for focused ultrasound therapy. 2015 IEEE International Ultrasonics Symposium (IUS). Taipei, Taiwan 21 Oct - 24 Nov 2015 Institute of Electrical and Electronics Engineers (IEEE). https://doi.org/10.1109/ULTSYM.2015.0506