Microscopic changes in the spinal extensor musculature in people with chronic spinal pain: a systematic review.

Journal article

Purushotham, S, Stephenson, R S, Sanderson, A, Abichandani, D, Greig, C, Gardner, A and Falla, D (2022). Microscopic changes in the spinal extensor musculature in people with chronic spinal pain: a systematic review. The spine journal : official journal of the North American Spine Society. https://doi.org/10.1016/j.spinee.2022.01.023

Publication dates
Authors	Purushotham, S, Stephenson, R S, Sanderson, A, Abichandani, D, Greig, C, Gardner, A and Falla, D
Abstract	Chronic spinal pain is one the most common musculoskeletal disorders. Previous studies have observed microscopic structural changes in the spinal extensor muscles in people with chronic spinal pain. This systematic review synthesizes and analyses all the existing evidence of muscle microscopic changes in people with chronic spinal pain. To assess the microscopy of spinal extensor muscles including the fiber type composition, the area occupied by fiber types, fiber size/cross sectional area (CSA) and narrow diameter (ND) in people with and without chronic spinal pain. Further, to compare these outcome measures across different regions of the spine in people with chronic neck, thoracic and low back pain. Systematic review with meta-analysis METHODS: MEDLINE (Ovid Interface), Embase, PubMed, CINAHL Plus and Web of Science were searched from inception to October 2020. Key journals, conference proceedings, grey literature and hand searching of reference lists from eligible studies were also searched. Two independent reviewers were involved in the selection process. Only studies examining the muscle microscopy of the spinal extensor muscles (erector spinae (ES) and/or multifidus (MF)) between people with and without chronic spinal pain were selected. The risk of bias from the studies was assessed using modified Newcastle Ottawa Scale and the level of evidence was established using the GRADE approach. Data were synthesized based on homogeneity on the methodology and outcome measures of the studies for ES and MF muscles and only four studies were eligible for analysis. All the five studies included were related to chronic low back pain (CLBP). Meta-analysis (inverse variance method for random effect to calculate mean difference and 95% CI) was performed for the ES fiber type composition by numbers for both type I and type II fibers (I =43% and 0% respectively indicating homogeneity of studies) and showed no difference between the people with and without CLBP with an overall effect estimate Z= 1.49 (p=0.14) and Z=1.06 (p=0.29) respectively. Meta-analysis was performed for ES fiber CSA for both type I and type II fibers (I =0 for both) and showed no difference between people with and without CLBP with an overall effect estimate Z= 0.08 (p=0.43) and Z=0.75 (p=0.45) respectively. Analysis was not performed for ES area occupied by fiber types and ND due to heterogeneity of studies and lack of evidence respectively. Similarly, meta-analysis was not performed for MF fiber type composition by numbers due to heterogeneity of studies. MF analysis for area occupied by fiber type, fiber CSA and ND did not yield sufficient evidence. For the ES muscle, there was no difference in fiber type composition and fiber CSA between people with and without CLBP and no conclusions could be drawn for ND for the ES. For the MF, no conclusions could be drawn for any of the muscle microscopy outcome measures. Overall, the quality of evidence is very low and there is very low evidence that there are no differences in microscopic muscle features between people with and without CLBP. [Abstract copyright: Copyright © 2022. Published by Elsevier Inc.]
Keywords	fiber size, cross-section area, narrow diameter, chronic low back pain; fiber type composition; multifidus; muscle; spinal extensors; erector spinae
Year	2022
Journal	The spine journal : official journal of the North American Spine Society
Publisher	Elsevier
ISSN	1878-1632
Digital Object Identifier (DOI)	https://doi.org/10.1016/j.spinee.2022.01.023
Online	05 Feb 2022
Publication process dates
Accepted	31 Jan 2022
Deposited	10 May 2022
Publisher's version	1-s2.0-S1529943022000444-main (1).pdf License CC BY 4.0 File Access Level Open

Permalink -

https://openresearch.lsbu.ac.uk/item/8z5z5

Download files

Publisher's version

	1-s2.0-S1529943022000444-main (1).pdf
License: CC BY 4.0
File access level: Open

48
total views
39
total downloads
3
views this month
1
downloads this month

Export as

Related outputs

Headache features in people with whiplash associated disorders: A scoping review.

Anarte-Lazo, E, Abichandani, D, Rodriguez-Blanco, C, Bernal-Utrera, C and Falla, D (2023). Headache features in people with whiplash associated disorders: A scoping review. Musculoskeletal science & practice. 66, p. 102802. https://doi.org/10.1016/j.msksp.2023.102802

Measures of neck muscle strength and their measurement properties in adults with chronic neck pain-a systematic review.

Abichandani, D., Ting, J.T.Y., Cancino, E.E., Althobaiti, S. and Falla, D. (2023). Measures of neck muscle strength and their measurement properties in adults with chronic neck pain-a systematic review. Systematic Reviews. 12 (1), p. 6. https://doi.org/10.1186/s13643-022-02162-5

Measurement properties of smartphone applications for the measurement of neck range of motion: a systematic review and meta analyses

Abichandani, D. and Elgueta-Cancino, E. (2022). Measurement properties of smartphone applications for the measurement of neck range of motion: a systematic review and meta analyses. BMC Musculoskeletal Disorders. 23 (138). https://doi.org/10.1186/s12891-022-05066-6

A meta-analysis and systematic review of changes in joint position sense and static standing balance in patients with whiplash-associated disorder

Abichandani, D., Mazaheri, M., Kingman, I., Treleaven, J. and Falla, D. (2021). A meta-analysis and systematic review of changes in joint position sense and static standing balance in patients with whiplash-associated disorder. PLoS ONE. https://doi.org/10.1371/journal.pone.0249659

Can People with Chronic Neck Pain Recognize Their Own Digital Pain Drawing?

Abichandani, D., Barbero, M., Cescon, C., Gallace, A., Punt, D., Sanchis-Sanchez, E. and Falla, D. (2020). Can People with Chronic Neck Pain Recognize Their Own Digital Pain Drawing? Pain Physician. 23, pp. E231-240. https://doi.org/10.36076/ppj.2020/23/E231

Effect of Lower Trapezius and Serratus Anterior Muscle Strengthening on Pain and Function in Patients with Chronic Mechanical Neck Pain

Abichandani, D. and Vora, K. (2017). Effect of Lower Trapezius and Serratus Anterior Muscle Strengthening on Pain and Function in Patients with Chronic Mechanical Neck Pain. International Journal of Science and Research . 6 (9), pp. 528-534.

Assessment of Anaerobic Power and Balance among Elite Indian Under-19 Football Players

Abichandani, D. and Hule, V. (2017). Assessment of Anaerobic Power and Balance among Elite Indian Under-19 Football Players. International Journal of Science and Research. 6 (9).

Comparison of Upper Limb Proprioception in Chronic Mechanical Neck Pain Patients with Age-Sex Matched Healthy Normals

Abichandani, D. and Parkar, B. (2017). Comparison of Upper Limb Proprioception in Chronic Mechanical Neck Pain Patients with Age-Sex Matched Healthy Normals. International Journal of Science and Research. 6 (3), pp. 1423 - 1428.

Comparison of Knee Joint Position Sense, Balance and Physical Function in Patients with Knee Osteoarthritis and Age-Sex Matched Normals

Abichandani, D. and Jetpurwala, H. (2017). Comparison of Knee Joint Position Sense, Balance and Physical Function in Patients with Knee Osteoarthritis and Age-Sex Matched Normals. International Journal of Science and Research . 6 (3).