Analytical expression for the NO concentration profile following NONOate decomposition in the presence of oxygen

Journal article

Rong, Z and Ye, Z (2016). Analytical expression for the NO concentration profile following NONOate decomposition in the presence of oxygen. Advances in Experimental Medicine and Biology. 923, pp. 435-441. https://doi.org/10.1007/978-3-319-38810-6_57
AuthorsRong, Z and Ye, Z
Abstract

© Springer International Publishing Switzerland 2016.We have derived an analytical expression for the time dependent NO concentration from NONOate donors in the presence of oxygen for the process of NO release from NO donors following autoxidation. This analytical solution incorporates the kinetics of the releases with the autoxidation and is used to fit the simulated NO concentration profile to the experimental data. This allows one to determine the NO release rate constant, k1, the NO release stoichiometric coefficient, vNO, and the NO autoxidation reaction rate constant, k2. This analytical solution also allows us to predict the real NO concentration released from NO donors under aerobic conditions, while vNO is reportedly two under aerobic conditions, it falls to lower values in the presence of oxygen.

KeywordsOxygen; Nitric Oxide; Nitric Oxide Donors; Oxidation-Reduction; Kinetics; Models, Chemical; Computer Simulation; Autoxidation; Decomposition; Mathematical mode; NONOate; Nitric oxide; Computer Simulation; Kinetics; Models, Chemical; Nitric Oxide; Nitric Oxide Donors; Oxidation-Reduction; Oxygen; 11 Medical And Health Sciences; General & Internal Medicine
Year2016
JournalAdvances in Experimental Medicine and Biology
Journal citation923, pp. 435-441
PublisherSpringer
ISSN0065-2598
Digital Object Identifier (DOI)https://doi.org/10.1007/978-3-319-38810-6_57
Publication dates
Print16 Aug 2016
Publication process dates
Deposited05 May 2018
Accepted01 Jan 2016
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Open
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